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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPPL2C
All Species:
14.85
Human Site:
S574
Identified Species:
40.83
UniProt:
Q8IUH8
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IUH8
NP_787078.1
684
74503
S574
R
G
A
G
D
L
D
S
N
P
G
E
D
T
T
Chimpanzee
Pan troglodytes
XP_523673
684
74537
S574
R
G
A
G
D
L
D
S
N
P
G
E
D
T
T
Rhesus Macaque
Macaca mulatta
XP_001115879
684
74573
S574
R
G
A
G
D
L
D
S
N
S
G
E
D
T
T
Dog
Lupus familis
XP_548046
660
70155
S560
H
L
A
G
D
L
D
S
N
L
E
E
A
E
A
Cat
Felis silvestris
Mouse
Mus musculus
A2A6C4
690
76248
S588
G
E
S
G
D
L
E
S
S
T
G
D
D
M
A
Rat
Rattus norvegicus
Q5PQL3
577
63718
V481
T
L
L
T
S
C
T
V
A
L
W
R
R
E
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507224
648
71872
F548
I
C
R
F
G
E
D
F
S
G
R
S
K
A
G
Chicken
Gallus gallus
Q5F383
596
66378
F500
M
F
W
T
G
S
G
F
A
K
D
L
P
Q
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782326
512
56836
Y416
A
F
S
V
C
N
V
Y
S
M
L
G
F
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
94.4
70.4
N.A.
69.1
41.5
N.A.
33
45.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Protein Similarity:
100
99.1
96.1
78.3
N.A.
80.2
57.5
N.A.
51
60
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
47.5
P-Site Identity:
100
100
93.3
53.3
N.A.
40
0
N.A.
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
93.3
53.3
N.A.
66.6
0
N.A.
13.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
45
0
0
0
0
0
23
0
0
0
12
12
23
% A
% Cys:
0
12
0
0
12
12
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
56
0
56
0
0
0
12
12
45
0
12
% D
% Glu:
0
12
0
0
0
12
12
0
0
0
12
45
0
23
0
% E
% Phe:
0
23
0
12
0
0
0
23
0
0
0
0
12
0
0
% F
% Gly:
12
34
0
56
23
0
12
0
0
12
45
12
0
12
12
% G
% His:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
12
0
0
12
0
0
% K
% Leu:
0
23
12
0
0
56
0
0
0
23
12
12
0
0
0
% L
% Met:
12
0
0
0
0
0
0
0
0
12
0
0
0
12
12
% M
% Asn:
0
0
0
0
0
12
0
0
45
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
23
0
0
12
0
12
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% Q
% Arg:
34
0
12
0
0
0
0
0
0
0
12
12
12
0
0
% R
% Ser:
0
0
23
0
12
12
0
56
34
12
0
12
0
0
0
% S
% Thr:
12
0
0
23
0
0
12
0
0
12
0
0
0
34
34
% T
% Val:
0
0
0
12
0
0
12
12
0
0
0
0
0
0
0
% V
% Trp:
0
0
12
0
0
0
0
0
0
0
12
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _